hepcinat-plus in india

Hepcinat-plus

• Hepcinat plus contains active ingredients of Sofosbuvir 400mg and Daclatasvir 60mg.  

• Hepcinat plus is a film coated tablet in which it composed of white to yellow colour solid and freely soluble in methanol and water. Hepcinat plus is a oval shape white colour tablet.

                Hepcinat-plus

                                                                     

          Absorption

• Peak plasma concentration of Hepcinat Plus ;
• Sofosbuvir: 0.5 to 2 hours
• Daclatasvir: within 2 hours
• Food should not be considered majorly, it should be administered with or without food.
• Oral bioavailability occurred in Daclatasvir is 67%

       Metabolism of Hepcinat Plus 

• Metabolism of sofosbuvir is involved in the liver, with the help of carboxyl esterase 1 or cathepsin A
• Nearly 99% of Daclatasvir is binding to protein and it is the substrate of CYP3A.

      Hepcinat plus tablet caused side effects

• Neutropenia
• Myalgia
• Irritability
• Pancytopenia
• Elevation of bilirubin, creatine kinase, lipase, AST & ALT
• HBV reoccurrence may occur
• Serious bradycardia while combining with amiodarone
• Fatigue
• A headache
• Insomnia
• Nausea
• Pruritus

Food-drug interaction:

• There is no possible food-drug interaction occurs during the therapy.
• Diet should be maintained after getting advice from the physician
• While concomitant with ribavirin, should not be taken on an empty stomach.